Musculoskeletal Disease

We are committed to improving lives for patients with musculoskeletal disease through translational research.

More about Musculoskeletal Disease research in Newcastle

Musculoskeletal diseases represent a significant area of NHS programme budget spend. This is set to rise, making them an NIHR highlight area with respect to disease burden and unmet clinical need.

At the NIHR Newcastle Biomedical Research Centre, we commit to improving treatments and outcomes for patients with musculoskeletal disease via a combination of scientific translational and clinical research.

While musculoskeletal conditions are not limited to the older population, their prevalence does increase with age and can therefore be more severe. The may also become more difficult to treat due to the presence of other ageing syndromes and multimorbidities.

Multimorbidity is an area of increasing importance in musculoskeletal disease, both because comorbidities influence the outcome of rheumatic disease, but also because the presence of comorbidities significantly complicates the management.

Musculoskeletal disease research in Newcastle

Newcastle has an outstanding reputation for translational research excellence relating to musculoskeletal conditions. Areas of strength in research relate to the development of novel biomarkers and stratified therapeutic approaches and devices for people living with musculoskeletal conditions such as:

  • Rheumatoid arthritis (RA)
  • Osteoarthritis (OA)
  • Progressive Systemic Sclerosis (PSS)

Our aims

Our current NIHR Newcastle Biomedical Research Centre Musculoskeletal research will build on these strengths in order to:

  • Embed research into every day practice by building an integrated musculoskeletal institute where patients, clinicians, clinical and laboratory researchers can come together in one space to formally and informally interact
  • Integrate laboratory research into the Newcastle Surgical Training Centre, providing state-of-the-art facilities for studying failed arthroplasties and arthroplasty biomechanics, enabling optimisation an stratification of surgical management strategies and devices

How we carry out research into musculoskeletal disease

A key strength in our translational research into musculoskeletal diseases is the links between patient cohorts and our experimental medicine, laboratory science and training facilities. This system allows us to carry out a ‘bottom up’ approach to our research; allowing our patient experiences, local clinical informatics and blood and tissue samples, to inform the research we carry out as part of the NIHR Newcastle Biomedical Research Centre.