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Ageing Syndromes

Role of immune ageing in cardiac inflammation of convalescent COVID-19 patients

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Principal Investigator: Professor Ioakim Spyridopoulos

Up to 10% of symptomatic patients in the UK have been suffering from consequences related to COVID-19 for more than three months (‘long-COVID syndrome’). Up…

The UK Multiple Long Term Conditions Research Registry

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Principal Investigator: Professor Miles Witham

Recruiting people with multiple long-term conditions is essential if research studies are to be representative of people cared for by clinical services. Finding the right…

Frailty in Chronic Limb Threatening Ischaemia (FraiLTI)

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Principal Investigator: Mr Sandip Nandhra

Full title: A prospective multicentre observational study to determine the incidence of frailty, sarcopenia and multimorbidity in chronic limb threatening ischaemia and the associated impact…

The gut microbiota as a tractable mechanistic target for dementia risk reduction: Impact of the Mediterranean diet and physical activity

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Principal Investigator: Dr Oliver Shannon

The study

This research will identify whether a Mediterranean Diet (MedDiet) positively shapes the gut microbiota and could be recommended as a ‘gut friendly’ diet.  The…

Using METformin to PREVENT progression to frailty for older people (MET-PREVENT) – a randomised controlled proof-of-concept trial

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Principal Investigator: Professor Miles Witham

Synopsis

The aim of the MET-PREVENT study is to determine whether the drug metformin, commonly used to treat diabetes, can improve physical function in older people…

STOP-TRANSIT study: Peri-procedural targets in toothache to stop transition to phantom neuropathic tooth pain

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Jamie Coulter

This research aims to allow the development of new therapeutics for orofacial pain patients.

The Study

Toothache is common, affecting up to 1 in 10 people in the UK and…

Sarcopenia and Frailty in early dementia with Lewy bodies

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Samantha Waite

This research investigates sarcopenia and frailty in individuals with prodromal dementia with Lewy bodies and Alzheimer’s disease.

The Study

Sarcopenia and frailty are both increasingly recognised in older patients, but…

Age-related bladder dysfunction and mitochondrial biology

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Nana-Jane Chipampe

This project aims to establish the suitability of measuring mitochondrial DNA (mtDNA) by sequencing Non-muscle Invasive Bladder Cancer patients’ urine.

The Study

Bladder cancer is the most common urinary tract…

The effect of ageing on the resolution of inflammation

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Wezi Sendama

This project aims to test the hypothesis that ageing impairs the clearance of inflammatory cells such as neutrophils from the lung after their recruitment in acute inflammation. In…

Unravelling the mutational landscape of acute lymphoblastic leukaemia in older adults to improve treatment.

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Thomas Creasey

Genomic characterisation of acute lymphoblastic leukaemia in older adults

The Study

Acute lymphoblastic leukaemia (ALL) is the most frequent cancer of childhood but the disease also becomes more common with…

Developing novel biomarkers of motor system changes in ageing humans.

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Stuart Maitland

Neurophysiology of age-related muscle weakness

The Study

As we grow old, we lose muscle bulk and strength. This muscle loss, termed ‘sarcopenia’, is a major burden on the health and…

Development of a novel imaging method “Motor Unit Magnetic Resonance Imaging” (MUMRI) to investigate motor unit activity in ageing.

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Matthew Birkbeck

Developing Magnetic Resonance Imaging (MRI) techniques to study functional muscle activity in ageing.

The Study

Sarcopenia is a condition affecting people over the age of 50 and is a progressive…