Skip to content

Dementia

CamEL Project – improving the diagnosis of early Lewy body disease

Featured image 2062020658

Principal Investigator: Dr Gemma Roberts

Full title: Improving the Interpretation of Cardiac Sympathetic Imaging with MIBG for More Accurate Diagnosis of Early Lewy Body Disease

Did you know that a heart…

“ESP+” – Extending and Improving ESP in the Diagnosis of Dementia with Lewy Bodies and Parkinson’s Disease

Featured image 1867849148

Principal Investigator: Dr Lina Gliaudelytė

Image: Fibrils of alpha-synuclein produced using ESP

Each year in the UK there are around 20,000 new cases of dementia with Lewy bodies (DLB) and 20,000…

Using EEG to understand and identify delirium in inpatients with Parkinson’s disease

Featured image 1626486493

Principal Investigator: Dr Rachael Lawson

Research has shown that people with Parkinson’s disease (PD) are at increased risk of delirium. Delirium is an acute neuropsychiatric syndrome associated with altered levels…

Networks and genes: towards a better understanding of cholinergic dysfunction in Lewy body dementia

Featured image 1776955544

Principal Investigator: Dr Jude Harrison

Lewy body dementia (LBD), which includes Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), is characterised by significant damage to key brain networks,…

Developing novel tools to accurately identify dementia subtypes: application of wearable based gait analysis and machine learning approaches

Featured image 1698077010

Principal Investigator: Rana Zia Ur Rehman

Many different subtypes of dementia have similarities in clinical presentation, but a more accurate diagnosis is important to allow individuals to understand and manage…

Understanding how local area deprivation, health inequality and multimorbidity contribute to progression of dementia and cognitive impairment

Featured image 340465715

Principal Investigator: Dr Calum Hamilton

The Study

As many as 40% of dementia cases may be preventable through addressing modifiable individual risk factors in earlier life. However, many of these factors…

The gut microbiota as a tractable mechanistic target for dementia risk reduction: Impact of the Mediterranean diet and physical activity

Featured image 445793625

Principal Investigator: Dr Oliver Shannon

The study

This research will identify whether a Mediterranean Diet (MedDiet) positively shapes the gut microbiota and could be recommended as a ‘gut friendly’ diet.  The…

Understanding how bile acids cause cognitive deficits in Primary Biliary Cholangitis (PBC)

Featured image 751895050

Lucy Gee

This project aims to investigate the specific effects bile acids have on cell populations within the brain, as well as the ability of drug treatments to reverse these…

Sarcopenia and Frailty in early dementia with Lewy bodies

Featured image 288137406

Samantha Waite

This research investigates sarcopenia and frailty in individuals with prodromal dementia with Lewy bodies and Alzheimer’s disease.

The Study

Sarcopenia and frailty are both increasingly recognised in older patients, but…

Brain dynamics as confirmatory biomarker of dementia with Lewy bodies versus Alzheimer’s disease – An electrophysiological study

Featured image 82810734

Ramtin Mehraram

This research focuses on assessing how the electrical activity of the brain is affected in the different forms of dementia. With this research he aims to contribute in…

Health Data Platform

Featured image 273036884

 

Principal Investigator: Dr Will Innes

This proof of principle project will apply advanced Machine Learning computer algorithms to obtain deeper insights from the data already collected and to realise the…

Cholinergic ResponsE in Early lewy body Disease: The CREED study

Featured image 1750748283

 

Principal Investigator: Professor John-Paul Taylor

Developing new ways to understand how people with Lewy body dementia (LBD) might respond best to an existing treatment and to help with the…