Skip to content

Neuromuscular Disease

Developing non-invasive biomarkers of skeletal muscle health in mitochondrial disease using Motor Unit MRI

Featured image 188128299

Principal Investigator: Professor Roger Whittaker

Mitochondrial diseases affect 1 in 4,500 people, with muscle weakness and fatigue being common symptoms. Several clinical trials have suggested exercise as an effective treatment,…

Muscle function as a mediator of ageing phenotype in people living with HIV: a basis for stratified intervention

Featured image 1247412470

Matthew Hunt

HIV is now a chronic manageable condition, but health span is less well preserved than lifespan. People living with HIV (PLWH) present a valuable model in which to…

Interrogating mitochondrial dysfunction in human facial appearance and ageing

Featured image 745087462

Roisin Stout

The main objective of this project is to investigate the role of mitochondrial dysfunction in ageing- specifically in relation to the skin.

The Study

Mitochondria are the batteries of the…

Age-related bladder dysfunction and mitochondrial biology

Featured image 658389090

Nana-Jane Chipampe

This project aims to establish the suitability of measuring mitochondrial DNA (mtDNA) by sequencing Non-muscle Invasive Bladder Cancer patients’ urine.

The Study

Bladder cancer is the most common urinary tract…

Developing novel biomarkers of motor system changes in ageing humans.

Featured image 324563506

Stuart Maitland

Neurophysiology of age-related muscle weakness

The Study

As we grow old, we lose muscle bulk and strength. This muscle loss, termed ‘sarcopenia’, is a major burden on the health and…

Development of a novel imaging method “Motor Unit Magnetic Resonance Imaging” (MUMRI) to investigate motor unit activity in ageing.

Featured image 1486108590

Matthew Birkbeck

Developing Magnetic Resonance Imaging (MRI) techniques to study functional muscle activity in ageing.

The Study

Sarcopenia is a condition affecting people over the age of 50 and is a progressive…

Identifying changes in proteome of single cells using imaging mass spectrometry

Featured image 629835463

 

Principal Investigator: Professor Doug Turnbull

This project aims to develop a new technique enabling the analysis of expression of multiple proteins in single cells in situ.

The Study

The main aim of…