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Research project

Role of immune ageing in cardiac inflammation of convalescent COVID-19 patients

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Principal Investigator: Professor Ioakim Spyridopoulos

Up to 10% of symptomatic patients in the UK have been suffering from consequences related to COVID-19 for more than three months (‘long-COVID syndrome’). Up…

Frailty in Chronic Limb Threatening Ischaemia (FraiLTI)

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Principal Investigator: Mr Sandip Nandhra

Full title: A prospective multicentre observational study to determine the incidence of frailty, sarcopenia and multimorbidity in chronic limb threatening ischaemia and the associated impact…

Harnessing human skin knockout models to discover CYLD mediated protective homeostatic mechanisms in skin cancer and neurodegenerative disease

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Principal Investigator: Dr Neil Rajan

Inherited skin tumour syndromes represent accelerated models of skin tumour formation, with multiple, early-onset tumours being a defining feature. This project will study inherited skin…

Musculoskeletal Remote pAtient centred cARe (MSK RADAR)

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Principal Investigator: Dr Arthur Pratt

Full project title: Musculoskeletal Remote pAtient centred cARe (MSK RADAR): A service delivery project to integrate remotely reported patient outcomes with the electronic record for…

UVB genomics and psoriasis

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Principal Investigator: Professors Nick J Reynolds

Full project title: Functional and genomic characterisation of ultraviolet-B on involved and uninvolved psoriatic skin: application towards understanding of environmental stress effects on ageing…

Developing novel tools to accurately identify dementia subtypes: application of wearable based gait analysis and machine learning approaches

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Principal Investigator: Rana Zia Ur Rehman

Many different subtypes of dementia have similarities in clinical presentation, but a more accurate diagnosis is important to allow individuals to understand and manage…

Exploring the commonalities in neurodegeneration in Parkinson’s disease and neuropathic pain to identify areas for therapeutic exploitation: ExCITE study

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Principal Investigator: Emma Beecroft

The study

Parkinson’s Disease (PD) and neuropathic pain (NP) often occur together, both conditions demonstrate an increase in prevalence with age. Pain is one of the most…

Dysregulated metabolic homeostasis in oropharyngeal mucosa as a common pathway in human multi systems disease

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Principal Investigators: Professor Chris Ward and Dr James Garnett

The Study

Preliminary work has demonstrated that altered glucose levels cause significant changes in metabolism in the cells of the nose.

Altered glucose…

Functional and single-cell genomic characterisation of atopic dermatitis endotypes

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Principal Investigators: Professor Muzlifah Haniffa and Professor Nick J Reynolds

We are combining pioneering single cell sequencing technology with our clinical expertise and well characterised cohorts of atopic dermatitis (eczema)…

Identifying changes in proteome of single cells using imaging mass spectrometry

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Principal Investigator: Professor Doug Turnbull

This project aims to develop a new technique enabling the analysis of expression of multiple proteins in single cells in situ.

The Study

The main aim of…

Developing objective assessment tools for measuring fatigue in clinical studies

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Principal Investigator: Professor Wan-Fai Ng

 

The ultimate aim of the study is to identify candidate biobehavioural parameters that can…

Chronic Cognitive Impairment in Cholestatic Liver Disease: Impact, Pathogenesis, Treatment and Relevance to Dementia

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Principal Investigator: Professor David Jones

To develop the essential tools to allow us to explore the utility of early OCA as a transformative treatment for cholestatic cognitive impairment.

The Study

People normally…