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Skin & Oral Disease

Harnessing human skin knockout models to discover CYLD mediated protective homeostatic mechanisms in skin cancer and neurodegenerative disease

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Principal Investigator: Dr Neil Rajan

Inherited skin tumour syndromes represent accelerated models of skin tumour formation, with multiple, early-onset tumours being a defining feature. This project will study inherited skin…

UVB genomics and psoriasis

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Principal Investigator: Professors Nick J Reynolds

Full project title: Functional and genomic characterisation of ultraviolet-B on involved and uninvolved psoriatic skin: application towards understanding of environmental stress effects on ageing…

Characterising the dynamic inter-relationships between polypharmacy and multiple long-term conditions

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Principal Investigator: Professor Nick Reynolds

Full project title: Characterising the dynamic inter-relationships between polypharmacy and multiple long-term conditions. Using artificial intelligence (AI) to map patient journeys into multimorbidity clusters in…

Exploring the commonalities in neurodegeneration in Parkinson’s disease and neuropathic pain to identify areas for therapeutic exploitation: ExCITE study

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Principal Investigator: Emma Beecroft

The study

Parkinson’s Disease (PD) and neuropathic pain (NP) often occur together, both conditions demonstrate an increase in prevalence with age. Pain is one of the most…

Dysregulated metabolic homeostasis in oropharyngeal mucosa as a common pathway in human multi systems disease

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Principal Investigators: Professor Chris Ward and Dr James Garnett

The Study

Preliminary work has demonstrated that altered glucose levels cause significant changes in metabolism in the cells of the nose.

Altered glucose…

STOP-TRANSIT study: Peri-procedural targets in toothache to stop transition to phantom neuropathic tooth pain

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Jamie Coulter

This research aims to allow the development of new therapeutics for orofacial pain patients.

The Study

Toothache is common, affecting up to 1 in 10 people in the UK and…

Interrogating mitochondrial dysfunction in human facial appearance and ageing

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Roisin Stout

The main objective of this project is to investigate the role of mitochondrial dysfunction in ageing- specifically in relation to the skin.

The Study

Mitochondria are the batteries of the…

Innovative data mining using deep learning advanced photoplethysmography pulse wave analysis for the assessment of endothelial dysfunction in systemic sclerosis and related cardiovascular conditions.

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Sadaf Iqbal

This project focuses on exploring the potential of simple, low-cost and portable Photoplethysmography (PPG) signals in the diagnosis of Systemic Sclerosis. It aims to use signal processing knowledge…

An investigation of the credentials of a novel lysine deacetylase as an age-related biomarker for periodontitis

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Christopher Dowson 

The aim of the project is to investigate the role of SIRT2 in periodontitis in cell culture models in vitro and as a diagnostic measure in vivo.

The Study

Periodontitis…

Investigating the role of Langhans type multinucleated giant cells in giant cell arteritis.

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Daniel Maunder 

The aim of this project is to investigate the formation & function of Langhans-type multinucleated giant cells to improve our understanding of giant cell arteritis.

The Study

Giant cell arteritis…

Scratching the surface: Gene signatures in pigmented skin lesions

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Principal Investigator: Dr Neil Rajan

This project aims to support research that underpins the understanding of skin cancer in the elderly population by exploring how gene signatures in melanomas vary…

Functional and single-cell genomic characterisation of atopic dermatitis endotypes

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Principal Investigators: Professor Muzlifah Haniffa and Professor Nick J Reynolds

We are combining pioneering single cell sequencing technology with our clinical expertise and well characterised cohorts of atopic dermatitis (eczema)…