While dementia is not exclusive to the older population, it is commonly associated with the cellular processes of ageing and is therefore a key priority area of research. In this theme, we focus on dementia caused by Lewy Body disease (LBD), which comprises people with Parkinson’s who develop dementia (PDD) and dementia with Lewy bodies (DLB), building on previous, ground-breaking work undertaken in an earlier phase of NIHR BRC funding at Newcastle, which established a differential diagnosis for this form of the disease, as well as improved understanding of the course of Dementia with Lewy Bodies.
With increasing societal impact and unmet therapeutic challenges, dementia remains a major UK government and NIHR priority. Our current Dementia theme builds on the work achieved under previous NIHR Newcastle BRC funding rounds and continues to focus on the delivery of world-class Lewy Body Disease (LBD) research.
We aim to impact positively upon:
- early, accurate diagnosis;
- understanding of the disease course and potential modifiers;
- understanding of the pathophysiology of key LBD-related symptoms;
- developing novel biomarkers for tracking LBDs;
- trialling protective treatments.
The theme is led by Professor David Burn, who is Professor of Movement Disorder Neurology in, and Pro-Vice Chancellor for, the Faculty of Medical Sciences at Newcastle University. Additionally he is an Honorary Consultant Neurologist with the Newcastle Hospitals, Chair of the NIHR Dementia Translational Research Collaboration and an NIHR Senior Investigator.