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Musculoskeletal Disease: About

Our Musculoskeletal Disease research theme builds on our development of novel biomarkers, stratified therapeutic approaches, and devices for patients with musculoskeletal conditions, through a combination of basic and translational research.

Newcastle has an outstanding reputation for translational research excellence in Musculoskeletal Disease, with a track record of innovation through linking exemplary patient cohorts from one of the busiest clinical musculoskeletal services in the UK, with excellent experimental medicine, laboratory science and training facilities.

The theme is led by John Isaacs, Professor of Clinical Rheumatology and an Honorary Consultant Rheumatologist with the Newcastle Hospitals. He is internationally renowned as a pioneer of translational rheumatoid arthritis (RA) research.

Deputy Theme Lead Fai Ng is Professor of Rheumatology at Newcastle University and Honorary Consultant Rheumatologist at the Newcastle Hospitals. He is an international leader in primary Sjögren’s syndrome (PSS) research and has established the UK primary Sjögren’s syndrome registry (, one of the world’s largest PSS cohorts and biobanks. Fai also leads the NIHR Bioresource Centre in PSS, is the Deputy Director of the Newcastle Clinical Research Facility (CRF), and has served as chief/principal investigator for many early phase clinical trials/experimental medicine studies in PSS.