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Ageing Projects

Using METformin to PREVENT progression to frailty for older people (MET-PREVENT) – a randomised controlled proof-of-concept trial

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Principle Investigator: Professor Miles Witham

Synopsis

The aim of the MET-PREVENT study is to determine whether the drug metformin, commonly used to treat diabetes, can improve physical function in older people…

STOP-TRANSIT study: Peri-procedural targets in toothache to stop transition to phantom neuropathic tooth pain

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Jamie Coulter

This research aims to allow the development of new therapeutics for orofacial pain patients.

The Study

Toothache is common, affecting up to 1 in 10 people in the UK and…

Sarcopenia and Frailty in early dementia with Lewy bodies

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Samantha Waite

This research investigates sarcopenia and frailty in individuals with prodromal dementia with Lewy bodies and Alzheimer’s disease.

The Study

Sarcopenia and frailty are both increasingly recognised in older patients, but…

Age-related bladder dysfunction and mitochondrial biology

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Nana-Jane Chipampe

This project aims to establish the suitability of measuring mitochondrial DNA (mtDNA) by sequencing Non-muscle Invasive Bladder Cancer patients’ urine.

The Study

Bladder cancer is the most common urinary tract…

The effect of ageing on the resolution of inflammation

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Wezi Sendama

This project aims to test the hypothesis that ageing impairs the clearance of inflammatory cells such as neutrophils from the lung after their recruitment in acute inflammation. In…

Unravelling the mutational landscape of acute lymphoblastic leukaemia in older adults to improve treatment.

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Thomas Creasey

Genomic characterisation of acute lymphoblastic leukaemia in older adults

The Study

Acute lymphoblastic leukaemia (ALL) is the most frequent cancer of childhood but the disease also becomes more common with…

Developing novel biomarkers of motor system changes in ageing humans.

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Stuart Maitland

Neurophysiology of age-related muscle weakness

The Study

As we grow old, we lose muscle bulk and strength. This muscle loss, termed ‘sarcopenia’, is a major burden on the health and…

Development of a novel imaging method “Motor Unit Magnetic Resonance Imaging” (MUMRI) to investigate motor unit activity in ageing.

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Matthew Birkbeck

Developing Magnetic Resonance Imaging (MRI) techniques to study functional muscle activity in ageing.

The Study

Sarcopenia is a condition affecting people over the age of 50 and is a progressive…

Investigating the impact of cellular senescence on muscle ageing

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Leena Habiballa

With age, our muscle mass and strength decline, leading to loss of function and capacity for physical activity, known as…

Muscle Ageing Sarcopenia Study Lifecourse (MASS_Lifecourse)

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Principal Investigator: Dr Richard Dodds

Establishing a life course cohort for advances in the prevention, diagnosis and treatment of sarcopenia.

 

The Study

Sarcopenia is the loss of muscle mass and function with…

TASKMASTER: TArgeting the SKeletal Muscle pump to Aid Standing in Elders with postuRal hypotension

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Principal Investigator: Dr James Frith

This study aims to develop an efficacious and acceptable new therapy; ultimately aiming to improve the quality of life of older people with Orthostatic Hypotension…

MASS (Muscle Ageing and Sarcopenia Studies)

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Principal Investigator: Professor Avan Sayer

Two pilot studies (MASS-PD, recruiting patients with Parkinsons disease, and MASS pilot, a pilot study for the main MASS lifecourse study) have completed successfully. The…