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Musculoskeletal Projects

Autologous Tolerogenic Dendritic Cells for Rheumatoid Arthritis (AuToDeCRA)

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Currently we rely on general dampening of immune responses (immunosuppression). At best, these approaches lead to symptom control, but they do not address the underlying cause and often…

Remote monitoring of disease and physical activity in patients with rheumatoid arthritis: a pilot study

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Principal Investigator: Dr Kenneth Baker

Rheumatoid arthritis is a common disease affecting 1 in 100 UK adults, causing joint pain, stiffness and fatigue. Patients with rheumatoid arthritis need close monitoring…

Musculoskeletal Remote pAtient centred cARe (MSK RADAR)

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Principal Investigator: Dr Arthur Pratt

Full project title: Musculoskeletal Remote pAtient centred cARe (MSK RADAR): A service delivery project to integrate remotely reported patient outcomes with the electronic record for…

Flow cytometry profiling of circulating flare-related lymphocytes to predict and understand flare and drug-free remission in rheumatoid arthritis

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Principal Investigator: Dr Ken Baker

Rheumatoid arthritis (RA) is a common disease affecting 1 in 100 UK adults, characterised by joint pain and swelling. With modern arthritis drugs, many patients…

RAMUS (Rheumatoid Arthritis Muscle Study)

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Principal Investigator: Professor John Isaacs

People with rheumatoid arthritis (RA) often have problems with muscle weakness and wasting (sarcopenia) as well as joint inflammation. In fact we think that the…

Innovative data mining using deep learning advanced photoplethysmography pulse wave analysis

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Sadaf Iqbal

Full title: Innovative data mining using deep learning advanced photoplethysmography pulse wave analysis for the assessment of endothelial dysfunction in systemic sclerosis and related cardiovascular conditions.

This project focuses…

Development of a diagnostic and therapeutic response biomarker for patients with rheumatoid arthritis

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Ian Herron 

The aim of this project is to develop and optimise a clinically feasible assay to detect a 3-gene biomarker and then test whether this biomarker has diagnostic, as…

Detection of somatic mutations in rheumatoid arthritis

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Fareeha Tariq 

The project takes a novel approach at the interface of a long-term condition (RA) and ageing.

The Study

Rheumatoid arthritis (RA) is an autoimmune disease most commonly diagnosed in aging…

Investigating the role of Langhans type multinucleated giant cells in giant cell arteritis.

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Daniel Maunder 

The aim of this project is to investigate the formation & function of Langhans-type multinucleated giant cells to improve our understanding of giant cell arteritis.

The Study

Giant cell arteritis…