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Neuromuscular Disease

Deputy Lead appointed President of the World Muscle Society

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Deputy Lead for the NIHR Newcastle BRC’s Neuromuscular theme, Professor Volker Straub, has been appointed President of the World Muscle Society

Professor Straub was unanimously elected from the 1st May,…

Relationship between skeletal muscle disorders and neurodegeneration

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In this NIHR Newcastle BRC funded study, researchers examine what links can be made between sarcopenia, an age-associated progressive muscle disorder, and neurodegenerative conditions such as Parkinson’s disease (PD)

Lead…

Muscle function as a mediator of ageing phenotype in people living with HIV: a basis for stratified intervention

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Matthew Hunt

HIV is now a chronic manageable condition, but health span is less well preserved than lifespan. People living with HIV (PLWH) present a valuable model in which to…

Interrogating mitochondrial dysfunction in human facial appearance and ageing

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Roisin Stout

The main objective of this project is to investigate the role of mitochondrial dysfunction in ageing- specifically in relation to the skin.

The Study

Mitochondria are the batteries of the…

Age-related bladder dysfunction and mitochondrial biology

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Nana-Jane Chipampe

This project aims to establish the suitability of measuring mitochondrial DNA (mtDNA) by sequencing Non-muscle Invasive Bladder Cancer patients’ urine.

The Study

Bladder cancer is the most common urinary tract…

Developing novel biomarkers of motor system changes in ageing humans.

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Stuart Maitland

Neurophysiology of age-related muscle weakness

The Study

As we grow old, we lose muscle bulk and strength. This muscle loss, termed ‘sarcopenia’, is a major burden on the health and…

Development of a novel imaging method “Motor Unit Magnetic Resonance Imaging” (MUMRI) to investigate motor unit activity in ageing.

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Matthew Birkbeck

Developing Magnetic Resonance Imaging (MRI) techniques to study functional muscle activity in ageing.

The Study

Sarcopenia is a condition affecting people over the age of 50 and is a progressive…

Prevention of mitochondrial disease: Mitochondrial donation

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Researchers in Newcastle were the first to show that they could prevent the transmission of mitochondrial DNA through IVF based techniques.

Researchers in Newcastle were the first to show that…

Identifying changes in proteome of single cells using imaging mass spectrometry

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Principal Investigator: Professor Doug Turnbull

This project aims to develop a new technique enabling the analysis of expression of multiple proteins in single cells in situ.

The Study

The main aim of…

Matthew Birkbeck (Trainee) – Conference oral presentation

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British Chapter – International Society of Magnetic Resonance in Medicine, 16/09/19

Oral Presentation – Non-Invasive Imaging of Human Motor Units