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Neuromuscular Projects

Exploring novel ways to monitor motor function

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Newcastle has been chosen as a clinical centre and a consortium partner for a project to develop non-invasive tools for measuring mobility in rare disease patients.

Volker Straub and Anna…

Study could lead to advancements in rare disease treatment

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A new study has solved the old enigma in mitochondrial DNA disorders and advances the prospect of enhanced treatments for patients.

An international team, some of which are supported by…

Developing non-invasive biomarkers of skeletal muscle health in mitochondrial disease using Motor Unit MRI

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Principal Investigator: Professor Roger Whittaker

Mitochondrial diseases affect 1 in 4,500 people, with muscle weakness and fatigue being common symptoms. Several clinical trials have suggested exercise as an effective treatment,…

Age-related bladder dysfunction and mitochondrial biology

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Nana-Jane Chipampe

This project aims to establish the suitability of measuring mitochondrial DNA (mtDNA) by sequencing Non-muscle Invasive Bladder Cancer patients’ urine.

The Study

Bladder cancer is the most common urinary tract…

Developing novel biomarkers of motor system changes in ageing humans.

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Stuart Maitland

Neurophysiology of age-related muscle weakness

The Study

As we grow old, we lose muscle bulk and strength. This muscle loss, termed ‘sarcopenia’, is a major burden on the health and…

Development of a novel imaging method “Motor Unit Magnetic Resonance Imaging” (MUMRI) to investigate motor unit activity in ageing.

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Matthew Birkbeck

Developing Magnetic Resonance Imaging (MRI) techniques to study functional muscle activity in ageing.

The Study

Sarcopenia is a condition affecting people over the age of 50 and is a progressive…