Immune cell characteristics mapped across multiple tissues
Experts have shed new light on the types and traits of immune cells that can be found in the human body, from early life to adulthood.
Previously underexplored immune cell…
Q&A with Dr Nusayhah Hudaa Gopee
Dr Hudaa Gopee has recently been awarded an MRC Training Fellowship. We spoke to her to find out more about…
Comparative analysis of microsatellite instability and somatic mismatch repair gene status in Lynch related skin and upper gastrointestinal cancers
Principal Investigator: Dr Neil Rajan
Lynch syndrome (LS) is a genetic cancer predisposition syndrome, characterised by an increased risk of developing a wide variety of tumours, most notably bowel, womb,…
Exploring conserved gene expression programmes across tissues in ageing
Principal Investigator: Dr Gary Reynolds
There have been dramatic increases in life expectancy in the UK and these changes are predicted to continue with around 8.6 million people in 50…
Living with rare disease
28 February is Rare Disease Day, which raises awareness for the 300 million people across the world living with a…
Translational advances in CYLD cutaneous syndrome (CCS)
Novel clinical trial and associated experimental study demonstrate feasibility in the topical treatment of CCS.
Patients with the inherited condition (CYLD cutaneous syndrome – CCS) develop multiple, painful, hair follicle…
Learning more about ‘giant cell arteritis’: a trainee’s story
Daniel Maunder studied for his PhD with the NIHR Newcastle BRC. He worked alongside Skin and Oral Disease theme lead, Professor Muzlifah Haniffa….
How blood and immune systems form in developing bone marrow
Researchers have found that in the space of just a few weeks, numerous blood and immune cell types emerge from developing bone marrow, including key white blood cells that…
Development study reveals origins of inflammatory bowel disease
A development study, led by one of Newcastle BRC’s theme leads, has produced publications outlining the origins of several diseases.
The papers, published in Nature, are the work of the…
Combining research and clinical care in dermatology: a trainee’s story
Dr Siobhan Muthiah is a Consultant with Newcastle Hospitals, who took part in a research project funded by the NIHR Newcastle BRC. She tells us how this has shaped…
Harnessing human skin knockout models to discover CYLD mediated protective homeostatic mechanisms in skin cancer and neurodegenerative disease
Principal Investigator: Dr Neil Rajan
Inherited skin tumour syndromes represent accelerated models of skin tumour formation, with multiple, early-onset tumours being a defining feature. This project will study inherited skin…
UVB genomics and psoriasis
Principal Investigator: Professors Nick J Reynolds
Full project title: Functional and genomic characterisation of ultraviolet-B on involved and uninvolved psoriatic skin: application towards understanding of environmental stress effects on ageing…