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Skin and Oral Disease

How blood and immune systems form in developing bone marrow

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Researchers have found that in the space of just a few weeks, numerous blood and immune cell types emerge from developing bone marrow, including key white blood cells that…

Development study reveals origins of inflammatory bowel disease

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A development study, led by one of Newcastle BRC’s theme leads, has produced publications outlining the origins of several diseases.

The papers, published in Nature, are the work of the…

Combining research and clinical care in dermatology: a trainee’s story

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Dr Siobhan Muthiah is a Consultant with Newcastle Hospitals, who took part in a research project funded by the NIHR Newcastle BRC. She tells us how this has shaped…

Harnessing human skin knockout models to discover CYLD mediated protective homeostatic mechanisms in skin cancer and neurodegenerative disease

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Principal Investigator: Dr Neil Rajan

Inherited skin tumour syndromes represent accelerated models of skin tumour formation, with multiple, early-onset tumours being a defining feature. This project will study inherited skin…

UVB genomics and psoriasis

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Principal Investigator: Professors Nick J Reynolds

Full project title: Functional and genomic characterisation of ultraviolet-B on involved and uninvolved psoriatic skin: application towards understanding of environmental stress effects on ageing…

Characterising the dynamic inter-relationships between polypharmacy and multiple long-term conditions

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Principal Investigator: Professor Nick Reynolds

Full project title: Characterising the dynamic inter-relationships between polypharmacy and multiple long-term conditions. Using artificial intelligence (AI) to map patient journeys into multimorbidity clusters in…

Exploring the commonalities in neurodegeneration in Parkinson’s disease and neuropathic pain to identify areas for therapeutic exploitation: ExCITE study

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Principal Investigator: Emma Beecroft

The study

Parkinson’s Disease (PD) and neuropathic pain (NP) often occur together, both conditions demonstrate an increase in prevalence with age. Pain is one of the most…

Dysregulated metabolic homeostasis in oropharyngeal mucosa as a common pathway in human multi systems disease

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Principal Investigators: Professor Chris Ward and Dr James Garnett

The Study

Preliminary work has demonstrated that altered glucose levels cause significant changes in metabolism in the cells of the nose.

Altered glucose…

The celebration: diversity, unconscious bias and research culture

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To celebrate the start of International Women’s Day, Newcastle BRC’s Professor Muzlifah Haniffa gave a talk on diversity and unconscious bias to members of the NU Women network.

The talk,…

Meet the researcher: Professor Muzlifah Haniffa

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In our fourth ‘Meet the researcher’ post, we talk to Muzlifah Haniffa, Professor Professor of Dermatology and Immunology at Newcastle…

Developmental origins of eczema and psoriasis discovered

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Scientists have created a highly detailed map of skin, which reveals that cellular processes from development are re-activated in cells from patients with inflammatory skin disease.

The researchers from the…

Experts in Newcastle collaborate on COVID-19 research, examining the immune system in detail

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In a recent pre-print paper, experts in Newcastle share research findings on a detailed examination of the immune system during COVID-19.

In collaboration with Cambridge University, Wellcome Sanger Institute, European…