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Skin and Oral Projects

Comparative analysis of microsatellite instability and somatic mismatch repair gene status in Lynch related skin and upper gastrointestinal cancers

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Principal Investigator: Dr Neil Rajan

Lynch syndrome (LS) is a genetic cancer predisposition syndrome, characterised by an increased risk of developing a wide variety of tumours, most notably bowel, womb,…

Exploring conserved gene expression programmes across tissues in ageing

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Principal Investigator: Dr Gary Reynolds

There have been dramatic increases in life expectancy in the UK and these changes are predicted to continue with around 8.6 million people in 50…

Harnessing human skin knockout models to discover CYLD mediated protective homeostatic mechanisms in skin cancer and neurodegenerative disease

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Principal Investigator: Dr Neil Rajan

Inherited skin tumour syndromes represent accelerated models of skin tumour formation, with multiple, early-onset tumours being a defining feature. This project will study inherited skin…

UVB genomics and psoriasis

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Principal Investigator: Professors Nick J Reynolds

Full project title: Functional and genomic characterisation of ultraviolet-B on involved and uninvolved psoriatic skin: application towards understanding of environmental stress effects on ageing…

Characterising the dynamic inter-relationships between polypharmacy and multiple long-term conditions

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Principal Investigator: Professor Nick Reynolds

Full project title: Characterising the dynamic inter-relationships between polypharmacy and multiple long-term conditions. Using artificial intelligence (AI) to map patient journeys into multimorbidity clusters in…

Exploring the commonalities in neurodegeneration in Parkinson’s disease and neuropathic pain to identify areas for therapeutic exploitation: ExCITE study

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Principal Investigator: Emma Beecroft

The study

Parkinson’s Disease (PD) and neuropathic pain (NP) often occur together, both conditions demonstrate an increase in prevalence with age. Pain is one of the most…

Dysregulated metabolic homeostasis in oropharyngeal mucosa as a common pathway in human multi systems disease

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Principal Investigators: Professor Chris Ward and Dr James Garnett

The Study

Preliminary work has demonstrated that altered glucose levels cause significant changes in metabolism in the cells of the nose.

Altered glucose…

STOP-TRANSIT study: Peri-procedural targets in toothache to stop transition to phantom neuropathic tooth pain

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Jamie Coulter

This research aims to allow the development of new therapeutics for orofacial pain patients.

The Study

Toothache is common, affecting up to 1 in 10 people in the UK and…