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Strategic project

Using METformin to PREVENT progression to frailty for older people (MET-PREVENT) – a randomised controlled proof-of-concept trial

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Principal Investigator: Professor Miles Witham

Synopsis

The aim of the MET-PREVENT study is to determine whether the drug metformin, commonly used to treat diabetes, can improve physical function in older people…

Muscle Ageing Sarcopenia Study Lifecourse (MASS_Lifecourse)

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Establishing a life course cohort for advances in the prevention, diagnosis and treatment of sarcopenia.

The Study

Sarcopenia is the loss of muscle mass and function with advancing years. It has…

Functional and single-cell genomic characterisation of atopic dermatitis endotypes

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Principal Investigators: Professor Muzlifah Haniffa and Professor Nick J Reynolds

We are combining pioneering single cell sequencing technology with our clinical expertise and well characterised cohorts of atopic dermatitis (eczema)…

Chronic Cognitive Impairment in Cholestatic Liver Disease: Impact, Pathogenesis, Treatment and Relevance to Dementia

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Principal Investigator: Professor David Jones

To develop the essential tools to allow us to explore the utility of early OCA as a transformative treatment for cholestatic cognitive impairment.

The Study

People normally…

Cholinergic ResponsE in Early lewy body Disease: The CREED study

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Principal Investigator: Professor John-Paul Taylor

Developing new ways to understand how people with Lewy body dementia (LBD) might respond best to an existing treatment and to help with the…