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Strategic project

Using METformin to PREVENT progression to frailty for older people (MET-PREVENT) – a randomised controlled proof-of-concept trial

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Principal Investigator: Professor Miles Witham

Synopsis

The aim of the MET-PREVENT study is to determine whether the drug metformin, commonly used to treat diabetes, can improve physical function in older people…

Muscle Ageing Sarcopenia Study Lifecourse (MASS_Lifecourse)

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Principal Investigator: Dr Richard Dodds

Establishing a life course cohort for advances in the prevention, diagnosis and treatment of sarcopenia.

 

The Study

Sarcopenia is the loss of muscle mass and function with…

Functional and single-cell genomic characterisation of atopic dermatitis endotypes

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Principal Investigators: Professor Muzlifah Haniffa and Professor Nick J Reynolds

We are combining pioneering single cell sequencing technology with our clinical expertise and well characterised cohorts of atopic dermatitis (eczema)…

Chronic Cognitive Impairment in Cholestatic Liver Disease: Impact, Pathogenesis, Treatment and Relevance to Dementia

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Principal Investigator: Professor David Jones

To develop the essential tools to allow us to explore the utility of early OCA as a transformative treatment for cholestatic cognitive impairment.

The Study

People normally…

Cholinergic ResponsE in Early lewy body Disease: The CREED study

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Principal Investigator: Professor John-Paul Taylor

Developing new ways to understand how people with Lewy body dementia (LBD) might respond best to an existing treatment and to help with the…