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Trainee Projects

Developing non-invasive biomarkers of skeletal muscle health in mitochondrial disease using Motor Unit MRI

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Principal Investigator: Professor Roger Whittaker

Mitochondrial diseases affect 1 in 4,500 people, with muscle weakness and fatigue being common symptoms. Several clinical trials have suggested exercise as an effective treatment,…

STOP-TRANSIT study: Peri-procedural targets in toothache to stop transition to phantom neuropathic tooth pain

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Jamie Coulter

This research aims to allow the development of new therapeutics for orofacial pain patients.

The Study

Toothache is common, affecting up to 1 in 10 people in the UK and…

Understanding how bile acids cause cognitive deficits in Primary Biliary Cholangitis (PBC)

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Lucy Gee

This project aims to investigate the specific effects bile acids have on cell populations within the brain, as well as the ability of drug treatments to reverse these…

Lifestyle as Therapy in Liver Disease

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Jadine Scragg

This feasibility study aims to assess the proposed recruitment strategies in a well-defined patient group with advanced Non-alcoholic fatty liver disease (NAFLD) and will determine whether…

Sarcopenia and Frailty in early dementia with Lewy bodies

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Samantha Waite

This research investigates sarcopenia and frailty in individuals with prodromal dementia with Lewy bodies and Alzheimer’s disease.

The Study

Sarcopenia and frailty are both increasingly recognised in older patients, but…

Muscle function as a mediator of ageing phenotype in people living with HIV: a basis for stratified intervention

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Matthew Hunt

HIV is now a chronic manageable condition, but health span is less well preserved than lifespan. People living with HIV (PLWH) present a valuable model in which to…

Interrogating mitochondrial dysfunction in human facial appearance and ageing

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Roisin Stout

The main objective of this project is to investigate the role of mitochondrial dysfunction in ageing- specifically in relation to the skin.

The Study

Mitochondria are the batteries of the…

Age-related bladder dysfunction and mitochondrial biology

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Nana-Jane Chipampe

This project aims to establish the suitability of measuring mitochondrial DNA (mtDNA) by sequencing Non-muscle Invasive Bladder Cancer patients’ urine.

The Study

Bladder cancer is the most common urinary tract…

Unravelling the mutational landscape of acute lymphoblastic leukaemia in older adults to improve treatment.

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Thomas Creasey

Genomic characterisation of acute lymphoblastic leukaemia in older adults

The Study

Acute lymphoblastic leukaemia (ALL) is the most frequent cancer of childhood but the disease also becomes more common with…

Developing novel biomarkers of motor system changes in ageing humans.

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Stuart Maitland

Neurophysiology of age-related muscle weakness

The Study

As we grow old, we lose muscle bulk and strength. This muscle loss, termed ‘sarcopenia’, is a major burden on the health and…

Innovative data mining using deep learning advanced photoplethysmography pulse wave analysis

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Sadaf Iqbal

Full title: Innovative data mining using deep learning advanced photoplethysmography pulse wave analysis for the assessment of endothelial dysfunction in systemic sclerosis and related cardiovascular conditions.

This project focuses…

Brain dynamics as confirmatory biomarker of dementia with Lewy bodies versus Alzheimer’s disease – An electrophysiological study

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Ramtin Mehraram

This research focuses on assessing how the electrical activity of the brain is affected in the different forms of dementia. With this research he aims to contribute in…