Liver Disease

Chronic liver disease is a major cause of poor quality of life and is a contributor to excess death, making it a significant concern for both patients and the NHS.

Our Liver Diseases theme links unique patient cohorts curated by Newcastle with basic research excellence in order to develop, with our partners, novel treatment approaches which we evaluate using our established translational platforms. We are also harnessing Newcastle’s world-class ageing biology research, developing innovative approaches to exploring the contribution made by ageing processes to the biology of liver disease.

Led by Dave Jones OBE, a Professor of Liver Immunology and Honorary Consultant Hepatlogist with Newcastle Hospitals, Dave is also Dean of the NIHR Academy and an NIHR Senior Investigator. He has an international reputation for his work in autoimmune liver disease and leads the UK-PBC research consortium (MRC Stratified Medicine), which has the largest cohort of fully phenotyped primary biliary cholangitis/cirrhosis (PBC) patients.

Deputy Theme Lead Quentin Anstee is Professor of Experimental Hepatology and an Honorary Consultant Hepatologist at Newcastle Hospitals, where he leads one of the largest NAFLD clinical services in the UK.

Liver Disease Theme People

Professor David Jones

Liver Disease Theme Lead and Dean NIHR Academy

Professor Quentin M Anstee

Liver Disease Deputy Theme Lead

Jadine Scragg

Trainee (Biomedical Researcher)

Laura Haigh

Trainee (NMAHP)

Lucy Gee

Trainee (Biomedical Researcher)

Naw April Phaw

Trainee (Doctor/Dentist)

Yang Bai

Trainee (Biomedical Researcher)

Liver Disease Projects

Understanding how bile acids cause cognitive deficits in Primary Biliary Cholangitis (PBC)

Lifestyle as Therapy in Liver Disease

Personalised Nutrition in Non-Alcoholic Fatty Liver Disease (NAFLD): Feasibility of a Nutrigenomic Therapeutic Approach

Chronic Cognitive Impairment in Cholestatic Liver Disease: Impact, Pathogenesis, Treatment and Relevance to Dementia