NIHR BioResource Centre Newcastle

This BioResource researches over 50 rare diseases areas. These include immunity, neuroscience, haematology, rheumatology, cardiovascular disease, and many more.

We use modern technologies to study the DNA of participants (whole-genome sequencing). We tie that genetic information to clinical information about the participants. These clinical characteristics are the participants ‘phenotype’.

The NIHR BioResource-Rare Diseases, recruits affected participants and, in some cases, their relatives.

Immune-Mediated Inflammatory Diseases (IMID) BioResource

IMIDs are a range of diseases that lack a defined cause but share responses of inflammation. They cause a significant burden of disease in the UK population.

The IMID BioResource focuses on three common IMIDs: psoriasis, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE).

We support research into the causes of these conditions and understand the factors that determine severity of IMID and response to treatment.

NAFLD is the most common cause of liver disease in Western countries, affecting approximately 30-40% of the UK population. It refers to a group of conditions where excess fat builds up in the liver of people who drink little or no alcohol.

We support research into the causes of NAFLD, to help understand the factors affecting the severity and responses to treatment. By doing this, we can begin to identify better treatments to reduce the effects of NAFLD or provide a cure.